The season premiere deals with Homer being diagnosed with narcolepsy, his breaking up with Marge, and falling for a pharmacist.Guest stars for this season include Blake Anderson, Kristen Bell, David Copperfield, Lena Dunham, Kelsey Grammer, Nick Kroll, Yo-Yo Ma, Edward James Olmos, Kevin Michael Richardson, and George Takei.Marge and Homer later realize they've made a terrible mistake and must go to New York to retrieve Lisa.
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This revelation shocks Patty and Selma, who decide to quit smoking once and for all and burn all their cigarettes, which unfortunately causes Jacqueline's house to burn down.
However, Selma's relapse causes an angry Patty to move in with Marge and Homer.
However, on July 7, he returned to the show after signing a new deal with five other cast members.
Homer and Marge go through a trial separation, during which Homer dates a pharmacist.
Meanwhile, Lisa creates an app that can predict the effect any post on social media will have. Berrera Sanjay's son Jay takes over the Kwik-E-Mart, but Apu is displeased when he turns it into a food market.
Guest stars: Stephen Merchant as Conrad and Kaitlin Olson as Quinn Bart experiences early puberty after drinking a milk substitute filled with bad hormones, and ends up competing with Skinner for the affections of his new teacher, Mrs. Meanwhile, Bart attempts to prank the new store, despite the fact that he told Homer he wouldn't prank anymore.
Guest stars: Bob Boilen, Kelsey Grammer as Sideshow Bob, Natalie Maines as Hettie (singing voice) and Kate Mc Kinnon as Hettie Lisa becomes a veterinarian after performing CPR on a raccoon, and learns a harsh lesson when the neglected class hamster, Nibbles, dies. Burns' lack of affection towards him, other characters attempt to find a boyfriend for him.